Effect of 6-fluoro-m-tyrosine on dopamine release and metabolism in rat striatum using in vivo microdialysis
作者： Thor D. Stein , Onofre T. DeJesus
DOI: 10.1016/S0006-8993(00)02976-0
关键词:
摘要: 6-[(18)F]Fluoro-m-tyrosine (FMT) is a positron emission tomography (PET) imaging agent for the aromatic L-amino acid decarboxylase enzyme. Its parent compound, L-m-tyrosine (LMT) induces behavioral effects in rodents via dopamine release. To assess potential pharmacologic effect of FMT, its role release and metabolism rat striatum was compared with LMT L-DOPA using vivo microdialysis. Results indicate that FMT will not have same dopamine-induced as LMT.
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