Antidiarrheal and antispasmodic activities of Vitex negundo are mediated through calcium channel blockade
作者： Munasib Khan , Abdul Jabbar Shah , Anwar Hassan Gilani
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摘要: Vitex negundo has reputation in the traditional medicine diarrhea and gut spasm. This study was carried out to provide possible pharmacological basis its medicinal use hyperactive disorders. In castor oil-induced diarrheal model, crude extract of V. , caused a dose-dependent protection (53-71%), similar loperamide. isolated rabbit jejunum preparation, inhibition spontaneous high K + -induced contractions, with EC 50 values 0.36 (0.22-0.61) 1.30 mg/mL (0.27-5.89; n=4-5), respectively, suggestive spasmolytic activity, mediated possibly through calcium channel blockade (CCB). The CCB activity further confirmed when pre-treatment tissue (0.03-0.3 mg/mL) rightward shift Ca ++ concentration-response curves (CRCs), diltiazem or loperamide. These data indicate that antidiarrheal effects are presence CCB-like constituent(s). DOI: http://dx.doi.org/10.3329/bjp.v8i3.15296 Bangladesh Journal Pharmacology Vol.8(3) 2013 317-322
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