[The erbB-related protooncogenes encoding growth factor receptors].

摘要: The c-erbB-2 gene was first identified by virtue of its cross-hybridization with v-erbB. Nucleotide sequence analysis complementary DNA clones suggested that the encodes a growth factor receptor similar to for EGF. Antibodies against carboxyl terminal protein immunoprecipitated 185-kDa glycoprotein which showed protein-tyrosine kinase activity in vitro. Despite extensive similarity between and EGF receptor, neither nor TGF-alpha bound protein. Phosphorylation stimulated TPA via C vivo. also induced phosphorylation This occurred not only on serine threonine residues but tyrosine residues. Preliminary data latter mediated receptor. Southern blot DNAs from primary tumors revealed tends be amplified adenocarcinomas, mostly stomach breast. By screening both human genomic cDNA libraries using v-yes as probe, we obtained c-yes gene, pseudogene c-yes, c-fgr c-src two novel yes-related genes, fyn lyn. Complete nucleotide lyn these genes encode proteins p60src size sequence.