Melatonin–Dopamine Interactions: From Basic Neurochemistry to a Clinical Setting

摘要: To review the interaction between melatonin and dopaminergic system in hypothalamus striatum its potential clinical use dopamine-related disorders central nervous system. Medline-based search on melatonin-dopamine interactions mammals. Melatonin. hormone produced by pineal gland at night. influences circadian seasonal rhythms, most notably sleep-wake cycle reproduction. The neurochemical basis of these activities is not understood yet. Inhibition dopamine release has been demonstrated specific areas mammalian (hypothalamus, hippocampus, medulla-pons, retina). Antidopaminergic have striatum. Dopaminergic transmission a pivotal role entrainment fetus, coordination body movement Recent findings indicate that may modulate pathways involved humans. In Parkinson patients may, one hand, exacerbate symptoms (because putative interference with release) and, other, protect against neurodegeneration (by virtue antioxidant properties effects mitochondrial activity). Melatonin appears to be effective treatment tardive dyskinesia. severe disorder associated long-term blockade postsynaptic D2 receptor antipsychotic drugs schizophrenic patients. play significant nonphotic photic biological clock as well fine-tuning motor These nature beneficial disorders.