Melatonin, Oxidative Stress, and the Aging Brain

摘要: The changes associated with brain aging are discussed emphasis on altered oxidative and inflammatory events mitochondrial dysfunction. Many of these exacerbated in a variety age-related neurologic diseases. This commonality has led to the idea that similar therapeutic approaches may be used treatment several apparently unrelated neurodegenerative disorders. When aspects diseases modeled experimental animals cell lines, application melatonin been reported advantageous. means by which can protective probably is mediated way activation receptors, subtypes identified. initiate sequence intracellular signaling transcription factors lead gene expression. culmination this cascade increased levels antioxidant enzymes depressed inflammation. Melatonin useful both retardation nonpathologic amelioration chronic disease aging. inexpensive nature ready availability together its very low toxicity reinforce need place beneficial properties agent firmer basis.