Melatonin: A Safe Nutraceutical and Clinical Agent

摘要: Abstract Melatonin is an indoleamine with the chemical name N-acetyl-5-methoxytryptamine and found in animals, plants, bacteria. It has endocrine properties both animals plants. biosynthesized from neurotransmitter, serotonin, which turn made essential amino acid, tryptophan. Because its 5-hydroxy charged groups are acetylated, it a relatively nonpolar compound. In mammals, melatonin several roles; involved circadian regulation modulation of reproductive immune responses, mood, aging. produced by pineal gland peripheral tissues, notably gut. liberated into bloodstream pineal, can be considered systemic hormone. Levels vary diurnally, being highest during hours darkness, also throughout life cycle, lowest among elderly. This chapter focuses on recent findings suggesting variety therapeutic applications supporting safety exogenously supplied melatonin. The potential molecular mechanisms underlying these potentially clinically beneficial uses discussed.