miRNA-Based Ovarian Cancer Diagnosis and Therapy

摘要: Ovarian cancer is the most lethal gynecological cancer. Two major obstacles facing increased patient survival rates are late diagnosis and lack of lasting, effective treatments. Numerous studies have shown that miRNAs altered in cells suggesting they play critical roles tumorigenesis. It has also been found possess a specific miRNA signature. In this chapter, we discuss ovarian signature promising impact circulating early treatment. We will focus on miRNA-based treatment utilizing inhibition or overexpression to alter Such therapy may consist alone combination with chemotherapy since can sensitize drugs reduce acquired chemoresistance. Although clinical trials using emerging, there remains need initiate