The changing understanding of ageing. Part 2: Body composition, metabolism and cell death.

摘要: This second of three discussions about ageing biology and diseases continues at the level organism, examining relationship among body composition, late life diseases. One view significant age-related mass loss in humans suggests that anabolic failure is associated with various precipitating factors may share anorexia common. Lean decline even partial should alert clinicians to monitor patients for emergence otherwise subclinical disease. Weight or clinical disease also be independent, thus creating an interwoven complex view. Recent data from Portuguese water dog genetics model suggest heritable play a role end metrics some histological changes, metric changes are themselves inter-related. While widespread inflammation hyperplasia were less frequent than expected, there exists nonetheless growth hormone (GH)-insulin-like factor (IGF-1)-insulin axis requires further exploration. Oxidative metabolism apoptosis reviewed briefly as examples cellular reflected gross phenotypes, underscoring nature many late-life