Matrix metalloproteinase 13: a potential intermediate between low expression of microRNA-125b and increasing metastatic potential of non-small cell lung cancer.

摘要: Recent findings have suggested that microRNAs may be involved in the regulation of metastasis malignant cancers such as non–small cell lung cancer (NSCLC). This study aimed to determine relationship between expression miR-125b and matrix metalloproteinase 13 (encoded by MMP-13 ) metastatic potential cells NSCLC. Expression levels transcripts proteins were analyzed quantitative real-time PCR immunohistochemistry, respectively, tumor tissues adjacent nontumor from 42 patients with The interaction associations clinicopathologic data analyzed. MiR-125 b decreased NSCLC tissue samples, which correlated an increased incidence lymph node metastases, pathologic stage, levels, early progression-free survival. Additionally, we demonstrated can directly downregulate protein inhibit invasive capabilities cells. negatively tumors, function through MMP-13.