Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling
作者： Yi-Shih Ma , Yu-Ping Hsiao , Ju-Hwa Lin , Shu-Chun Hsu , Fu-Shin Chueh
DOI: 10.1002/TOX.21962
关键词:
摘要: Crude extract of Rheum palmatum L. (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated anti-metastasis effects CERP on LS1034 human colorectal cancer cells vitro and examined potential mechanisms its effects. significantly inhibited cell migration invasion cells. We also found that protein levels matrix metalloproteinases-2 (MMP-2) metalloproteinases-9 (MMP-9), cytosolic NF-kB p65, RHO A, ROCK 1. Furthermore, GRB2, SOS1, MKK7, FAK, Rho 1, VEGF, PKC, AKT, phosphor-AKT (Thr308), Cyclin D, iNOS, COX2, p-ERK1/2, p-JNK1/2, p-p38, p-c-jun, MMP-2, MMP-9, MMP-1, MMP-7, MMP-10, UPA increased level Ras conclusion, our results suggest may be as a novel agent treatment colon
sci-hub.se 参考文章(45)
Swadesh K Das, Sujit K Bhutia, Timothy P Kegelman, Leyla Peachy, Regina A Oyesanya, Santanu Dasgupta, Upneet K Sokhi, Belal Azab, Rupesh Dash, Bridget A Quinn, Keetae Kim, Paola M Barral, ZZ Su, Habib Boukerche, Devanand Sarkar, Paul B Fisher, MDA-9/syntenin: a positive gatekeeper of melanoma metastasis. Frontiers in Bioscience. ,vol. 17, pp. 1- 15 ,(2012) , 10.2741/3911
L A Julien, D M Vo, A G Thorson, Current controversies in colon and rectal cancer. Minerva Chirurgica. ,vol. 65, pp. 677- 693 ,(2010)
Mary Tagliaferri, Isaac Cohen, Bobbi Hamilton, Debasish Tripathy, Mark Shoemaker, Michael J. Campbell, Antiproliferative activity of Chinese medicinal herbs on breast cancer cells in vitro. Anticancer Research. ,vol. 22, pp. 3843- 3852 ,(2002)
Suzanne A. Eccles, Elisabeth A. Bone, Wayne Thomas, Gary M. Box, Peter D. Brown, William J. Court, Control of lymphatic and hematogenous metastasis of a rat mammary carcinoma by the matrix metalloproteinase inhibitor batimastat (BB-94) Cancer Research. ,vol. 56, pp. 2815- 2822 ,(1996)
Kinya Shinoda, Masahiko Shibuya, Suguru Hibino, Yasushi Ono, Kuniko Matsuda, Akira Takemura, Datong Zou, Yutaka Kokubo, Akiko Takechi, Shoji Kudoh, A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line. International Journal of Oncology. ,vol. 22, pp. 281- 288 ,(2003) , 10.3892/IJO.22.2.281
Jai-Sing Yang, Guang-Wei Chen, Te-Chun Hsia, Heng-Chien Ho, Chin-Chin Ho, Meng-Wei Lin, Song-Shei Lin, Ru-Duan Yeh, Siu-Wan Ip, Hsu-Fung Lu, Jing-Gung Chung, Diallyl disulfide induces apoptosis in human colon cancer cell line (COLO 205) through the induction of reactive oxygen species, endoplasmic reticulum stress, caspases casade and mitochondrial-dependent pathways. Food and Chemical Toxicology. ,vol. 47, pp. 171- 179 ,(2009) , 10.1016/J.FCT.2008.10.032
Jun Ma, Lei Zhang, Weina Han, Tingting Shen, Cui Ma, Yun Liu, Xiaowei Nie, Mengmeng Liu, Yajuan Ran, Daling Zhu, Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells Journal of Lipid Research. ,vol. 53, pp. 1093- 1105 ,(2012) , 10.1194/JLR.M024398
Yi-Shih Ma, Shu-Wen Weng, Meng-Wei Lin, Chi-Cheng Lu, Jo-Hua Chiang, Jai-Sing Yang, Kuang-Chi Lai, Jing-Pin Lin, Nou-Ying Tang, Jaung-Geng Lin, Jing-Gung Chung, Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model. Food and Chemical Toxicology. ,vol. 50, pp. 1271- 1278 ,(2012) , 10.1016/J.FCT.2012.01.033
MANN-JEN HOUR, SHIH-CHANG TSAI, HSI-CHIN WU, MENG-WEI LIN, JING-GUNG CHUNG, JIN-BIN WU, JO-HUA CHIANG, MINORU TSUZUKI, JAI-SING YANG, Antitumor effects of the novel quinazolinone MJ-33: inhibition of metastasis through the MAPK, AKT, NF-κB and AP-1 signaling pathways in DU145 human prostate cancer cells. International Journal of Oncology. ,vol. 41, pp. 1513- 1519 ,(2012) , 10.3892/IJO.2012.1560
Ozgur Kutuk, Huveyda Basaga, Apoptosis signalling by 4-hydroxynonenal: a role for JNK–c-Jun/AP-1 pathway Redox Report. ,vol. 12, pp. 30- 34 ,(2007) , 10.1179/135100007X162329