Preoperative Chemotherapy Followed by Surgery Compared With Primary Surgery in Resectable Stage I (Except T1N0), II, and IIIa Non–Small-Cell Lung Cancer
作者： Alain Depierre , Bernard Milleron , Denis Moro-Sibilot , Sylvie Chevret , Elisabeth Quoix
DOI: 10.1200/JCO.20.1.247
关键词:
摘要: PURPOSE: To evaluate whether preoperative chemotherapy (PCT) could improve survival in resectable stage I (except T1N0), II, and IIIA non–small-cell lung cancer (NSCLC). PATIENTS AND METHODS: A randomized trial compared PCT to primary surgery (PRS). consisted of two cycles mitomycin (6 mg/m2, day 1), ifosfamide (1.5 g/m2, days 1 3) cisplatin (30 3), additional postoperative for responding patients. In both arms, patients with pT3 or pN2 disease received thoracic radiotherapy. RESULTS: Three hundred fifty-five eligible were randomized. Overall response was 64%. There toxic deaths. Postoperative mortality 6.7% the arm 4.5% PRS (P = .38). Median 37 months (95% confidence interval [CI], 26.7 48.3) 26.0 CI, 19.8 33.6) .15). Survival differences between arms increased from 3.8% 1.3% 25.1%) at year 8.6% 2.64% 24.4%)...
jco.org参考文章(22)
Robert J. Ginsberg, Lucius D. Hill, Robert T. Eagan, Paul Thomas, Clifton F. Mountain, Jean Deslauriers, Willard A. Fry, Ralph O. Butz, Melvyn Goldberg, Paul F. Waters, Donald P. Jones, Peter Pairolero, Lawrence Rubinstein, F. Griffith Pearson, Modern thirty-day operative mortality for surgical resections in lung cancer. The Journal of Thoracic and Cardiovascular Surgery. ,vol. 86, pp. 654- 658 ,(1983) , 10.1016/S0022-5223(19)39080-4
Goldie Jh, Coldman Aj, A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer treatment reports. ,vol. 63, pp. 1727- 1734 ,(1979)
David R. Cox, Regression Models and Life-Tables Springer Series in Statistics. ,vol. 34, pp. 527- 541 ,(1992) , 10.1007/978-1-4612-4380-9_37
Nael Martini, Betty J. Flehinger, The role of surgery in N2 lung cancer. Surgical Clinics of North America. ,vol. 67, pp. 1037- 1049 ,(1987) , 10.1016/S0039-6109(16)44341-0
Tsuguo Naruke, Tomoyuki Goya, Ryosuke Tsuchiya, Keiichi Suemasu, The Importance of Surgery to Non-Small Cell Carcinoma of Lung with Mediastinal Lymph Node Metastasis The Annals of Thoracic Surgery. ,vol. 46, pp. 603- 610 ,(1988) , 10.1016/S0003-4975(10)64717-0
Jack A Roth, E.Neely Atkinson, Frank Fossella, Ritsuko Komaki, M.Bernadette Ryan, J.B Putnam, Jin Soo Lee, Hari Dhingra, Louis De Caro, Marvin Chasen, Waun Ki Hong, Long-term follow-up of patients enrolled in a randomized trial comparing perioperative chemotherapy and surgery with surgery alone in resectable stage IIIA non-small-cell lung cancer Lung Cancer. ,vol. 21, pp. 1- 6 ,(1998) , 10.1016/S0169-5002(98)00046-4
Clifton F. Mountain, A new international staging system for lung cancer Chest. ,vol. 89, pp. 225- 233 ,(1986) , 10.1378/CHEST.89.4_SUPPLEMENT.225S
S. L. Parker, T. Tong, S. Bolden, P. A. Wingo, Cancer statistics, 1997 CA: A Cancer Journal for Clinicians. ,vol. 47, pp. 5- 27 ,(1997) , 10.3322/CANJCLIN.47.1.5
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
T. LE CHEVALIER, R. ARRIAGADA, MICHÈLE TARAYRE, MARIE-JOSÉ LACOMBE-TERRIER, AGNÈS LAPLANCHE, ELIZABETH QUOIX, PIERE RUFFIE, MICHEL MARTIN, JEAN-YVES DOUILLARD, Significant effect of adjuvant chemotherapy on survival in locally advanced non-small-cell lung carcinoma. Journal of the National Cancer Institute. ,vol. 84, pp. 58- 58 ,(1992) , 10.1093/JNCI/84.1.58