Design, synthesis and preliminary biological evaluation of a focused combinatorial library of stereodiverse carbohydrate-scaffold-based peptidomimetics.
作者： Nicolas Moitessier , Sylvie Dufour , Françoise Chrétien , Jean Paul Thiery , Bernard Maigret
DOI: 10.1016/S0968-0896(00)00256-X
关键词:
摘要: A focused combinatorial library of 126 mimetics the RGD sequence based on sugar scaffolds have been rationally constructed using molecular modeling, with a particular emphasis stereodiversity library. liquid phase, mix and divide synthesis was used, active compounds being identified by orthogonal libraries recursive deconvolution strategies.
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