Relationship between obesity and race in predicting adverse pathologic variables in patients undergoing radical prostatectomy.

摘要: Abstract Objectives. To determine whether obesity is associated with more advanced prostate cancer (PCa) in radical prostatectomy patients and to explore the ethnic variability body mass index (BMI) as a potential explanation for racial differences PCa risk. Methods. A multi-institutional retrospective analysis of clinical pathologic parameters was performed on data from 860 undergoing between 1992 1998. Patient height weight used calculate BMI, which categorized into obese (BMI 30 kg/m2 or greater), overweight 25 kg/m2), normal less) groups. Age, serum prostate-specific antigen level, stage, Gleason score each group were compared. The distribution BMI four groups also determined. Results. Of patients, 171 (20%) obese, 425 (49%) overweight, 264 (31%) normal. presented at younger mean age (62 years, P = 0.001), had higher scores (6.7, 0.002), likelihood 7 greater (71%, 0.003), lower chance organ-confined (46%, 0.050). highest blacks, followed by whites Asians, blacks significantly grade cancers (P 0.045). In multiple logistic regression race, only remained an independent predictor grade. Conclusions. Obese present pathologically cancers. Blacks have than other and, same time, BMIs. These findings suggest that may part account