Methods of diagnosing a clinical subtype of Crohn's disease with features of ulcerative colitis

作者: Stephan R. Targan , Eric A. Vasiliauskas , Jerome I. Rotter , Huiying Yang , Scott E. Plevy

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摘要: The present invention provides a method of diagnosing clinical subtype Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are in patient with CD, where the presence pANCA indicates CD features ulcerative colitis (UC). also detecting an Arg241 allele at ICAM-1 locus colitis. In addition, pANCA-positive CD.

参考文章(23)
Talin Haritunians, Stephan R. Targan, Jerome I. Rotter, Dermot P. Mcgovern, Kent D. Taylor, Methods of diagnosing ulcerative colitis and crohn's disease ,(2012)
Giuseppe Malizia, Antonino Calabrese, Mario Cottone, Massimo Raimondo, Ludwik K. Trejdosiewicz, Chris J. Smart, Lorenzo Oliva, Luigi Pagliaro, Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease Gastroenterology. ,vol. 100, pp. 150- 159 ,(1991) , 10.1016/0016-5085(91)90595-C
R. T. Patel, R. Stokes, D. Birch, J. Ibbotson, M. R. B. Keighley, Influence of total colectomy on serum antineutrophil cytoplasmic antibodies in inflammatory bowel disease. British Journal of Surgery. ,vol. 81, pp. 724- 726 ,(2005) , 10.1002/BJS.1800810535
Roy Proujansky, Paul T. Fawcett, Kathleen M. Gibney, William R. Treem, Jeffrey S. Hyams, Examination of anti-neutrophil cytoplasmic antibodies in childhood inflammatory bowel disease. Journal of Pediatric Gastroenterology and Nutrition. ,vol. 17, pp. 193- 197 ,(1993) , 10.1097/00005176-199308000-00011
Donald E. Staunton, Steven D. Marlin, Christian Stratowa, Michael L. Dustin, Timothy A. Springer, Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families Cell. ,vol. 52, pp. 925- 933 ,(1988) , 10.1016/0092-8674(88)90434-5
A SAXON, F SHANAHAN, C LANDERS, T GANZ, S TARGAN, A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease The Journal of Allergy and Clinical Immunology. ,vol. 86, pp. 202- 210 ,(1990) , 10.1016/S0091-6749(05)80067-3
J. Y. Sung, Francis K. L. Chan, John Lawton, Joseph C. K. Leung, C. T. Liew, Nancy W. Y. Leung, Ronald Hsu, Kar-Neng Lai, Anti-neutrophil cytoplasmic antibodies (ANCA) and inflammatory bowel diseases in Chinese Digestive Diseases and Sciences. ,vol. 39, pp. 886- 892 ,(1994) , 10.1007/BF02087438
SE Plevy, SR Targan, H Yang, D Fernandez, JI Rotter, H Toyoda, Tumor necrosis factor microsatellites define a Crohn's disease- associated haplotype on chromosome 6 Gastroenterology. ,vol. 110, pp. 1053- 1060 ,(1996) , 10.1053/GAST.1996.V110.PM8612993
Stephan R. Targan, Loren Karp Murphy, Clarifying the causes of Crohn's Nature Medicine. ,vol. 1, pp. 1241- 1243 ,(1995) , 10.1038/NM1295-1241
EA Vasiliauskas, SE Plevy, CJ Landers, SW Binder, DM Ferguson, H Yang, JI Rotter, A Vidrich, SR Targan, Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup Gastroenterology. ,vol. 110, pp. 1810- 1819 ,(1996) , 10.1053/GAST.1996.V110.PM8964407