Status of hepatitis B infection - a decade after hepatitis B vaccination of susceptible Nicobarese, an indigenous tribe of Andaman & Nicobar (A&N) islands with high hepatitis B endemicity.

摘要: Background & objectives: Andaman and Nicobar Islands of India, home to six primitive tribes, constituting about 10 per cent the total population these have been detected with high endemicity hepatitis B infection. During 2000, a 936 individuals ≤ 45 yr, negative for surface antigen (HBsAg) antibody anti-HBs were vaccinated three doses recombinant DNA vaccine in two villages Car Islands. The present study was undertaken evaluate impact vaccination respect persistence antibodies incidence new infections, prevalence gene mutations among Nicobarese community ten years after vaccination. Methods: Follow up samples collected from 211 who had received back control group 515 non-vaccinated individuals. HBsAg, anti-HBc assay results compared groups. HBV extracted sequenced all detection mutation. Genotyping serotyping viruses performed. Results: showed that 85.3 persons retained protective level individuals, 54.2 presence indicating an exposure overall HBsAg positivity studies reduced 7.4 vaccination. Anti-HBc positive 60.6 57 respectively. Overall breakthrough infection 8.5 predominant genotype serotype circulating tribal populations D ayw3, Interpretation conclusions: this reduction pool carriers because which helped reducing carrier rate also, probably due increase herd immunity source Further need be done long term benefits tribes.