Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial

摘要: UNLABELLED Epidemiological studies suggest a dose-response relationship exists between physical activity and cognitive outcomes. However, no direct data from randomized trials to support these indirect observations. The purpose of this study was explore the possible aerobic exercise dose on cognition. Underactive or sedentary participants without impairment were one four groups: no-change control, 75, 150, 225 minutes per week moderate-intensity semi-supervised for 26-weeks in community setting. Cognitive outcomes latent residual scores derived battery 16 tests: Verbal Memory, Visuospatial Processing, Simple Attention, Set Maintenance Shifting, Reasoning. Other outcome measures cardiorespiratory fitness (peak oxygen consumption) function functional health. In intent-to-treat (ITT) analyses (n = 101), increased perceived disability decreased dose-dependent manner across 4 groups. No other exercise-related effects observed ITT analyses. Analyses restricted individuals who exercised per-protocol 77) demonstrated that Attention improved equivalently all groups compared controls present Processing. A clear fitness. benefits apparent at low doses with visuospatial higher but only those adhered protocol. An individual’s response better predictor gains than (i.e., duration) thus maximizing an may be important therapeutic target achieving benefits. TRIAL REGISTRATION ClinicalTrials.gov NCT01129115.