Engineered receptor/ligand system for delivery of therapeutic agents
作者： Nicholas Muzyczka , Hector Ruben Mendez-Gomez
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摘要: Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent subject utilizing an engineered receptor-ligand system, such as dockerin-cohesin system. As described herein, previously-developed systems for delivering agents tissue interest have drawbacks that not been addressed date. For example, with respect the blood-brain barrier (BBB) blood- cerebrospinal fluid (BCSFB), both which hamper brain, others relied on use endogenously expressed receptors, like transferrin receptor, assist across barriers.
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