Perinatal hyperinsulinism as possible predisposing factor for diabetes mellitus, obesity and enhanced cardiovascular risk in later life

摘要: The importance of the intrauterine and neonatal metabolic environment as possible teratogenic determinants predispositions to diabetes, obesity cardiovascular diseases is discussed. Epidemiological, clinical experimental results suggest that gestational diabetes or even slightly impaired glucose tolerance during pregnancy are important risk factors for development an increased Type II- I susceptibility in offspring. In addition, early prenatal undernutrition might also predispose enhanced II whereas perinatal overnutrition seems enhance predominantly susceptibility. this context, fetal and/or hyperinsulinism occurring a critical period brain leading permanent malorganization hypothalamic regulation centres metabolism hence malprogramming hypothalamo-pancreatic system, discussed reason lifelong view epidemiological findings, epigenetic maternofetal transmission such acquired persistent modifications can run over several generations, mediated by hyperglycaemia hyperinsulinism. conclusion, partial prophylaxis mellitus, appears be prevention - mild forms well overnutrition.