The effect of bromocriptine treatment on sexual functioning and depressive symptoms in women with mild hyperprolactinemia

摘要: Abstract Background Elevated prolactin levels are associated with sexual dysfunction in women. No previous study has investigated the effect of dopamine agonists on functioning Methods The enrolled 30 young women mild hyperprolactinemia (serum range between 25 and 50 ng/mL), 15 whom were later treated bromocriptine (5–10 mg daily), as well 14 age- weight-matched healthy All completed a questionnaire evaluating female function (Female Sexual Function Index – FSFI) presence severity depressive symptoms (Beck Depression Inventory Second Edition BDI-II). Results Women had lower total FSFI score, scores all domains (desire, arousal, lubrication, dyspareunia), BDI-II score than control Bromocriptine increased tended to reduce score. Moreover, drug normalized desire, lubrication dyspareunia, improved orgasm satisfaction this action correlated changes an improvement insulin sensitivity. observed untreated controls. Conclusions treatment improves slightly affects elevated is related its prolactin-lowering metabolic effects.