Pharmacogenomics of cancer chemotherapy-induced toxicity.
作者： C Ryan Miller , Howard L McLeod
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摘要: Pharmacogenomics is the study of inherited differences in interindividual drug disposition and effects. A major goal this effort cancer chemotherapy avoidance severe, potentially life-threatening toxicity for patients. Genetic polymorphisms drug-metabolizing enzymes other molecules involved are responsible much many agents. This review will discuss clinically relevant examples gene that influence experimental tools have been utilized discovering toxicity-related polymorphisms.
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