Immunomorphologic lymph node changes in rats bearing experimental breast tumors.

摘要: In this paper regional lymph nodes draining tumors and also nonregional have been studied at the light- electron-microscopic levels. These were obtained from rats bearing long-evolving autochthonous breast cancers. They compared with a control group of same age. A morphometric quantitative analysis was done to evaluate immunologically competent cell populations. experimental there no differences between distal in tumor challenge. However, when group, appeared. The changes involved diminution paracortical area stimulation plasma cells medullary cords. Ultrastructurally, lymphoblasts paracortex germinal centers, suggesting active lymphopoiesis. addition, many showed morphologic evidence involution or other alterations. It is suggested that similar behavior grows for long period time, finding contributes our knowledge systemic implications lymphatic system.