Synthesis of deuterated opiate glucuronides

作者: Raymond Albert Schep , Phuong Thi Ngoc Pham , Duc Tien Nguyen , Trinh Duc Nguyen , Hoa Duc Nguyen

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摘要: A method of synthesizing deuterated morphine-3β-glucuronide, morphine-6β-glucuronide, and codeine-6β-glucuronide is disclosed. The chemicals are used as internal standards for mass spectrometry analyses morphine, heroin, codeine uses. They also useful in the study metabolism morphine codeine.

参考文章(4)
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John A. Lawson, Joseph I. DeGraw, Michael Anbar, Synthesis of morphine-d5 and codeine-d8 Journal of Heterocyclic Chemistry. ,vol. 13, pp. 593- 595 ,(1976) , 10.1002/JHET.5570130334