Olanzapine counteracts reduction of brain-derived neurotrophic factor and TrkB receptors in rat hippocampus produced by haloperidol.
作者： Vinay Parikh , Mohammad M. Khan , Sahebarao P. Mahadik
DOI: 10.1016/J.NEULET.2003.10.079
关键词:
摘要: Recently, we have reported studies in rats showing that the atypical antipsychotic olanzapine (OLZ), contrast to haloperidol (HAL), was not associated with reduction of markers central cholinergic neurons as well decrements cognitive performance after chronic exposure. We compared effect 45 day exposure HAL (2 mg/kg per day) OLZ (10 on brain-derived neurotrophic factor (BDNF)) and its high affinity receptor TrkB rat hippocampus. Since use is presently preferred over patients, effects post-treatment HAL-induced changes expression BDNF were also investigated. administered days HAL, but OLZ, significantly reduced levels These paralleled receptors. Furthermore, markedly restored treatment reductions both receptors
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sci-hub.se 参考文章(24)
Herbert Y. Meltzer, Psychopharmacology : the third generation of progress Raven Press. ,(1987)
David J. Kupfer, Floyd E. Bloom, Psychopharmacology: The Fourth Generation of Progress ,(1995)
Ou Bai, Jennifer Chlan-Fourney, Rudy Bowen, David Keegan, Xin-Min Li, Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after treatment with antipsychotic drugs Journal of Neuroscience Research. ,vol. 71, pp. 127- 131 ,(2003) , 10.1002/JNR.10440
Jun-Shan Mu, Wei-Ping Li, Zhi-Bin Yao, Xin-Fu Zhou, Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats. Brain Research. ,vol. 835, pp. 259- 265 ,(1999) , 10.1016/S0006-8993(99)01592-9
Susan D Croll, Nancy Y Ip, Ronald M Lindsay, Stanley J Wiegand, Expression of BDNF and trkB as a function of age and cognitive performance Brain Research. ,vol. 812, pp. 200- 208 ,(1998) , 10.1016/S0006-8993(98)00993-7
DanielR Weinberger, Cell biology of the hippocampal formation in schizophrenia. Biological Psychiatry. ,vol. 45, pp. 395- 402 ,(1999) , 10.1016/S0006-3223(98)00331-X
Daniel R. Weinberger, Implications of Normal Brain Development for the Pathogenesis of Schizophrenia Archives of General Psychiatry. ,vol. 44, pp. 660- 669 ,(1987) , 10.1001/ARCHPSYC.1987.01800190080012
Anne-Françoise Steulet, Raymond Bemasconi, Therese Leonhardt, Pierre Martin, Christine Grünenwald, Serge Bischoff, Micheline Heinrich, Viviane Bandelier, Laurent Maître, Effects of selective dopamine D1 and D2 receptor agonists on the rate of GABA synthesis in mouse brain. European Journal of Pharmacology. ,vol. 191, pp. 19- 27 ,(1990) , 10.1016/0014-2999(90)94092-C
H. Kang, E. Schuman, Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus Science. ,vol. 267, pp. 1658- 1662 ,(1995) , 10.1126/SCIENCE.7886457
Richard Jed Wyatt, Ioline D Henter, The effects of early and sustained intervention on the long-term morbidity of schizophrenia Journal of Psychiatric Research. ,vol. 32, pp. 169- 177 ,(1998) , 10.1016/S0022-3956(97)00014-9