Therapieresistentes Pyoderma gangraenosum Eine Behandlung mit Mycophenolatmofetil und Cyclosporin A

摘要: A 68-year old woman presented with ulcerations on the calves that had occurred spontaneously. The very painful lesions both clinically and histologically showed characteristics of pyoderma gangrenosum. During hospitalization she was treated corticosteroids (oral, i.v., topically), clofazimine, cyclophosphamide, intravenous immune globulin, cyclosporine local), dapsone, thalidomide sodium cromoglycate (topically) without any benefit. Finally, when mycophenolate mofetil (CellCept) (oral) (oral), her skin continuous improvement. topical application thrombocytic growth factors (cytokines) probably accelerated granulation. Eight weeks after initiating this treatment could be covered split thickness grafts. Our observation suggests mofetil, a novel immunosuppressive agent which has thus far been used almost exclusively in transplantation medicine, may an effective therapeutic modality combination for