Therapeutic management of pyoderma gangrenosum.

摘要: Pyoderma gangrenosum (PG) is a primarily noninfectious inflammatory skin disease resulting in large ulcers that can spread rapidly showing undermined violaceous borders and necrotic, purulent base. PG was first described the 19th early 20th centuries (1,2). Similar to Sweet’s syndrome, belongs dermatoses, which are histologically characterized by an accumulation of neutrophils without any discernible microbial pathogens. often develops after minor trauma, consistent with phenomenon Koebnerization, but it also occurs preceding injury (3–5). Owing its numerous links rheumatic diseases, communityand hospital-based rheumatologists consulted regularly regarding differential diagnosis, long-term prognosis, current treatment options. Although few controlled trials have been performed, recent years body data has accumulated from case reports small studies including novel options; this widened therapeutic armamentarium considerably will be discussed detail review.