Inhibition of human gastric carcinoma cell growth by atofluding derivative N3-o-toluyl-fluorouracil
作者： Jian Liu
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摘要: AIM: To evaluate the growth inhibition efficacy of atofluding derivative N3-o-toluyl-fluorouracil (TFU) on human gastric carcinoma cell lines SGC-7901 and MKN-45. METHODS: Cell by TFU was measured MTT clonogenic assays without or with liver microsomal enzymes. Xenografts cancer cells in nude mice were employed to study anti-proliferative effects vivo. RESULTS: inhibited MKN-45 cells. However, inhibitory not significant. The rates enhanced presence enzymes, ranging 4.73%-48.57% 9.0%-62.02% In vivo, delayed mice. 40.49%, 63.24%, 75.98% 40.76%, 61.41%, 82.07% when oral doses 25, 50, 100 mg/kg, respectively. treatment generally well tolerated less than 20% reduction body weight. CONCLUSION: inhibits are increased may be associated sustaining release 5-fluorouracil (5-FU) mediated
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