Human metapneumovirus infection in hospitalized children with acute respiratory disease in Korea.

摘要: Human metapneumovirus (hMPV) is a recently isolated virus, mostly associated with acute lower respiratory infection in children, of which symptoms are similar to those syncytial virus (RSV) infection. The aim our study was determine the frequency hMPV hospitalized children tract disease Korea. Nasal aspirates from infections under 15 yr old between December 2003 and February 2005 were included study. Each sample analyzed for RSV, adenovirus, influenza A B, parainfluenza by indirect fluorescent assay (IFA). F-gene sequences used PCR detection sequencing hMPV. In total 381 samples, negative samples any viral pathogen could not be identified IFA 231 cases. detected using reverse transcriptase-PCR (RT-PCR) 28 (12.1%) who infected another viruses. hMPV-infected diagnosed as having pneumonia, bronchiolitis, bronchial asthma exacerbation, croup, upper Most RT-PCR positive collected winter season. These results suggest that may responsible causing Korean children.