Invasive Fungal Infections in Patients with Acute Leukemia and Hematopoietic Stem Cell Transplant Recipients

摘要: Patients with acute leukemia (AL) and hematologic stem cell transplant (HCT) recipients are at increased risk for the development of invasive fungal infections (IFI) due to prolonged neutropenia severe immunosupression. The incidence IFI in these patients has recent years [1], which likely reflects changes clinical practice including escalation treatment intensity; more frequent use unrelated, mismatched or alternative donors as source; rising number multiple transplantations; T-cell depleted grafts [2-3]. associated high morbidity mortality AL represent a leading cause infectious allogeneic HCT (allo-HCT) recipients. Therefore, effective preventive strategies, accurate diagnostic techniques optimal approaches required an management