New developments in malaria diagnostics Monoclonal antibodies against Plasmodium dihydrofolate reductase-thymidylate synthase, heme detoxification protein and glutamate rich protein
作者： Johanna H. Kattenberg , Inge Versteeg , Stephanie J. Migchelsen , Iveth J. González , Mark D. Perkins
关键词:
摘要: Currently available rapid diagnostic tests (RDTs) for malaria show large variation in sensitivity and specificity, there are concerns about their stability under field conditions. To improve current RDTs, monoclonal antibodies (mAbs) novel antigens have been developed screened possible use new tests. Three antigens, glutamate rich protein (GLURP), dihydrofolate reductase-thymidylate synthase (DHFR-TS) heme detoxification (HDP), were selected based on literature searches. Recombinant produced used to immunize mice. Antibody-producing cell lines subsequently the resulting specificity against Plasmodium falciparum vivax. The most optimal antibody couples affinity (expressed as dissociation constants, KD) detection limit of crude antigen extract from P. 3D7 culture. highest KD values 0.10 nM ± 0.01...
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