Malaria diagnostics and surveillance in the post-genomic era.

作者: N.W. Lucchi , J. Oberstaller , J.C. Kissinger , V. Udhayakumar

DOI: 10.1159/000345607

关键词:

摘要: Genome sequences are available for 3 human-infecting malaria parasites, Plasmodium falciparum, P. vivax and knowlesi, population genomics data many endemic regions. This review summarizes how genomic have been used to develop new, species-specific molecular targets better diagnosis. The combination of bioinformatics has identify new sequence suitable diagnostic applications assess their viability within the context global variation. selection criteria maximized sensitivity specificity novel targets. At least one target from each species was found be diagnosis with some advantages over existing methods. promise using genome sensitive, genus- or methods other pathogens public health interest is strong. undertaking together what we envision as future in 'omic' era discussed.

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