Expression of the voltage-sensing phosphatase gene in the chick embryonic tissues and in the adult cerebellum.
作者： Shinji Yamaguchi , Naoya Aoki , Takaaki Kitajima , Yasushi Okamura , Koichi J Homma
DOI: 10.4161/19420889.2014.970502
关键词:
摘要: Voltage-sensing phosphatase (VSP) consists of a transmembrane voltage sensor domain (VSD) and the cytoplasmic with phosphoinositide-phosphatase activities. It operates as directly translates membrane potential into phosphoinositide turnover by coupling VSD to domain. VSPs are evolutionarily conserved from marine invertebrate up humans. Recently, we demonstrated that ectopic expression chick ortholog VSP, Gg-VSP, in fibroblast cell line caused characteristic process outgrowths. Co-expression PTEN suppressed such morphological change, suggesting VSP regulates shape increasing PI(3,4)P2. However, vivo function Gg-VSP remains unclear. Here, showed embryos is expressed stomach, mesonephros, pharyngeal arch, limb bud, somites, floor plate neural tube, notochord. In addition, both transcripts protein were found cerebellar Purkinje neurons. These findings pr...
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