Interleukin 12 and direct cytotoxicity of spleen lymphocytes to Listeria innocua-phagocyting syngeneic macrophages in C57BL/6 and BALB/c mice.

摘要: Production of interleukin 12 (IL-12) during cytotoxic reaction C57BL/6 and BALB/c spleen lymphocytes or their subpopulations: T+B, T, CD4+ CD8+ cells to L. innocua-phagocyting syngeneic macrophages was examined. The effector cell donors were untreated innocua-infected. number surviving bacteria in phagocytes tested IL-12 level culture supernatants reacting determined. mice, resistant Listeria infection, found develop stronger cytotoxicity bacteria-phagocyting than mice. responsible for that phenomenon phenotype. produced only nonspecific T cells. It is suggested the innate resistance mice dependent on ability a specific production.