Etiologic Agents of Central Nervous System Infections among Febrile Hospitalized Patients in the Country of Georgia

摘要: Objectives: There is a large spectrum of viral, bacterial, fungal, and prion pathogens that cause central nervous system (CNS) infections. As such, identification the etiological agent requires multiple laboratory tests accurate diagnosis clinical epidemiological information. This hospital-based study aimed to determine main causes acute meningitis encephalitis enhance capacity for CNS infection diagnosis. Methods: Children adults patients clinically diagnosed with or were enrolled at four reference health centers. Cerebrospinal fluid (CSF) was collected bacterial culture, in-house multiplex RT-PCR testing conducted herpes simplex virus (HSV) types 1 2, mumps virus, enterovirus, varicella zoster (VZV), Streptococcus pneumoniae, HiB Neisseria meningitidis. Results: Out 140 patients, mean age 23.9 years, 58% children. Bacterial viral etiologies determined in 51% patients. Five pneumoniae cultures isolated from CSF. Based on PCR analysis, 25 positive S. 6 N. meningitidis, H. influenzae. Viral identified infections enterovirus (n=26), VZV (n=4), HSV-1 (n=2). No patient HSV-2. Conclusions: Study findings indicate enteroviruses are this cohort. The utility molecular diagnostics pathogen combined knowledge provided by investigation may improve outcomes cases Georgia.