作者: I Ueno , I Hirono , N Nakano
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摘要: To explain why quercetin, a mutagenic flavonoid distributed widely in edible plants, showed no carcinogenicity experimental animals, overall metabolic fate of the drug was pursued using radiolabeled compound. [4-(14)C]Quercetin administered orally or intraperitoneally to male ACI rats and its distribution, metabolism excretion were studied by autoradiography and/or quantitation radioactivity, chemical analysis. [14C]Quercetin also intravenously, bile duct-cannulated radioactivities CO2 expired, bile, urine feces measured. elucidate structure flavonoids urine, urinary derived from given non-labeled quercetin diet analyzed chemically. When [14C]-quercetin orally, around 20% [14C]quercetin absorbed digestive tract, more than 30% decomposed yield 14CO2 excreted unchanged feces. The rapidly into within 48 hours as glucuronide sulfate conjugates [14C]quercetin, 3'-O-monomethyl 4'-O-monomethyl [14C]quercetin. present data indicate that lack rat is attributable neither poor absorption tract nor microbial degradation tract. Efficient elimination may be one reason carcinogenicity.