Changes in the Expression of Pre-Replicative Complex Genes in hTERT and ALT Pediatric Brain Tumors.
作者： Aurora Irene Idilli , Francesca Pagani , Emanuela Kerschbamer , Francesco Berardinelli , Manuel Bernabé
关键词:
摘要: Background: The up-regulation of a telomere maintenance mechanism (TMM) is common feature cancer cells and hallmark cancer. Routine methods for detecting TMMs in tumor samples are still missing, whereas telomerase targeting treatments becoming available. In paediatric cancers, alternative lengthening telomeres (ALT) found subset sarcomas malignant brain tumors. ALT non-canonical developed by with no-functional telomerase. Methods: To identify drivers and/or markers ALT, we performed differential gene expression analysis between two zebrafish models juvenile tumors, that differ only the adopted cells: one while other telomerase-dependent. Results: Comparative identified five genes pre-replicative complex, ORC4, ORC6, MCM2, CDC45 RPA3 as upregulated ALT. We searched correlation levels complex cohort cancers counter-correlation complex. Moreover, group 20 patients confirmed association increased RPA decreased H3K9me3 localization at telomeres. Conclusions: Our study suggests mechanisms may act driver telomeric DNA replication chromatin status identifies could be exploited precise prognostic therapeutic purposes.
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