Neonatal Lupus Syndromes: Clinical Features

摘要: Publisher Summary Disease in the offspring parallels presence of maternal antibodies fetal and neonatal circulation disappears, except for congenital heart block (CHB), with clearance by eighth month postnatal life. The transient hematologic abnormalities skin disease neonate reflect effect passively acquired autoantibodies on those organ systems that have capacity continual regeneration. In contrast, these regenerative processes, apparently, do not occur cardiac tissue; complete is irreversible to date. manifestations this autoimmune syndrome closely mimic observed adolescents or adults systemic lupus erythematosus (SLE), while rarely, if ever, present same patients. CHB then termed “isolated CHB” absence structural may be causally related block, such as heterotaxia, single ventricle, endocardial cushion defects, congenitally-corrected transposition great arteries (ventricular inversion), but it include lesions, patent ductus arteriosus, secundum atrial septal defect, small ventricular etc.