Strength in Diversity: Nuclear Export of Viral RNAs.

摘要: The nuclear export of cellular mRNAs is a complex process that requires the orchestrated participation many proteins are recruited during early steps mRNA synthesis and processing. This strategy allows cell to guarantee conformity messengers accessing cytoplasm translation machinery. Most transcripts exported by exportin dimer Nuclear RNA factor 1 (NXF1)–NTF2-related protein (NXT1) transcription–export (TREX1). Some do not possess all common messenger characteristics use either variants NXF1–NXT1 pathway or CRM1, different exportin. Viruses whose synthesized in nucleus (retroviruses, vast majority DNA viruses, influenza viruses) exploit both these pathways. Viral hijack machinery via secondary structures recognized factors and/or viral adapter proteins. way, succeed escaping host surveillance system efficiently for translation, allowing infectious cycle proceed. review gives an overview mechanisms presents detailed insights into most important strategies viruses forms their RNAs from cytoplasm.