Neural Mechanisms of Circadian Regulation of Natural and Drug Reward.

摘要: Circadian rhythms are endogenously generated near 24-hour variations of physiological and behavioral functions. In humans, disruptions to the circadian system associated with negative health outcomes, including metabolic, immune, psychiatric diseases, such as addiction. Animal models suggest bidirectional relationships between drugs abuse, whereby desynchrony, misalignment, or disruption may promote vulnerability drug use transition addiction, while exposure abuse entrain, disrupt, perturb timing system. Recent evidence suggests natural (i.e., food) rewards influence overlapping neural circuitry, modulate responses these stimuli. Environmental disruptions, shifting schedules shorter/longer days, food intake, certain mutations genes that control cellular altered reward. We highlight more recent findings associating reward function, linking environmental genetic related circuitry.