Serotonin release measured in the human brain: a PET study with [ 11 C]CIMBI-36 and d-amphetamine challenge

作者: David Erritzoe , Abhishekh H. Ashok , Graham E. Searle , Alessandro Colasanti , Samuel Turton

DOI: 10.1038/S41386-019-0567-5

关键词:

摘要: Positron emission tomography (PET) enables non-invasive estimation of neurotransmitter fluctuations in the living human brain. While these methods have been applied to dopamine and some other transmitters, 5-hydroxytryptamine (5-HT; Serotonin) release has proved be challenging. Here we demonstrate utility novel 5-HT2A receptor agonist radioligand, [11C]CIMBI-36, a d-amphetamine challenge evaluate synaptic 5-HT changes Seventeen healthy male volunteers received [11C]CIMBI-36 PET scans before 3 h after an oral dose (0.5 mg/kg). Dynamic data were acquired over 90 min, total volume distribution (VT) frontal cortex cerebellum derived from kinetic analysis using MA1. The binding potential (BPNDfrontal) was calculated as (VTfrontal/VTcerebellum) − 1. ∆BPNDfrontal = 1 − (BPNDfrontal post-dose/BPNDfrontal baseline) used index release. Statistical inference tested by means paired Students t-test evaluating reduction post-amphetamine BPNDfrontal. Following administration, BPNDfrontal reduced 14 ± 13% (p = 0.002). Similar effects observed cortical regions examined exploratory analysis. is sensitive serotonin brain, when combined with challenge, evaluation brain system neuropsychiatric disorders, such major depression Parkinson’s disease enabled.

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