Mixed blood chimerism in T cell-depleted bone marrow transplant recipients: evaluation using DNA polymorphisms.
作者： S Bretagne , M Vidaud , M Kuentz , C Cordonnier , T Henni
DOI: 10.1182/BLOOD.V70.5.1692.1692
关键词:
摘要: We have used DNA sequence polymorphism analysis to document engraftment after T cell-depleted bone marrow transplantation (BMT), with a selected panel of four probes. In contrast nondepleted BMT recipients, the patients who received exhibited mixed blood chimerism. This mosaicism was observed before graft failure or relapse in six patients. However, five other patients, this chimerism not followed by these complications follow-up 9 31 months transplantation. Our results support hypothesis that transplanted cells may help maintain eliminating host can cause failure.
ashpublications.org
sci-hub.se 参考文章(14)
R Williamson, K E Davies, H H Ropers, P Wieacker, P L Pearson, J Zimmer, S Bhattacharya, H J Cooke, Toward a complete linkage map of the human X chromosome: regional assignment of 16 cloned single-copy DNA sequences employing a panel of somatic cell hybrids. American Journal of Human Genetics. ,vol. 36, pp. 265- 276 ,(1984)
ED Thomas, JW Singer, A Keating, R Ramberg, R McGuffin, JE Sanders, G Sale, PJ Fialkow, Long-term stable hematopoietic chimerism following marrow transplantation for acute lymphoblastic leukemia: a case report with in vitro marrow culture studies. Blood. ,vol. 62, pp. 869- 872 ,(1983) , 10.1182/BLOOD.V62.4.869.869
BR Blazar, HT Orr, DC Arthur, JH Kersey, AH Filipovich, Restriction fragment length polymorphisms as markers of engraftment in allogeneic marrow transplantation. Blood. ,vol. 66, pp. 1436- 1444 ,(1985) , 10.1182/BLOOD.V66.6.1436.1436
PJ Martin, JA Hansen, CD Buckner, JE Sanders, HJ Deeg, P Stewart, FR Appelbaum, R Clift, A Fefer, RP Witherspoon, Effects of In Vitro Depletion of T Cells in HLA-Identical Allogeneic Marrow Grafts Blood. ,vol. 66, pp. 664- 672 ,(1985) , 10.1182/BLOOD.V66.3.664.664
RG Knowlton, VA Brown, JC Braman, D Barker, JW Schumm, C Murray, T Takvorian, J Ritz, H Donis-Keller, Use of Highly Polymorphic DNA Probes for Genotypic Analysis Following Bone Marrow Transplantation Blood. ,vol. 68, pp. 378- 385 ,(1986) , 10.1182/BLOOD.V68.2.378.378
JAMES FERRARA, JEFFREY LIPTON, SAMUEL HELLMAN, STEVEN BURAKOFF, PETER MAUCH, Engraftment following T-cell-depleted marrow transplantation. I. The role of major and minor histocompatibility barriers. Transplantation. ,vol. 43, pp. 461- 467 ,(1987) , 10.1097/00007890-198704000-00001
Sylvia D. Lawler, Marion C. Baker, Helen Harris and, G. R. Morgenstern, Cytogenetic studies on recipients of allogeneic bone marrow using the sex chromosomes as markers of cellular origin British Journal of Haematology. ,vol. 56, pp. 431- 443 ,(1984) , 10.1111/J.1365-2141.1984.TB03973.X
Yutaka Nakahori, Kounosuke Mitani, Masao Yamada, Yasuo Nakagome, A human Y-chromosome specific repeated DNA family (DYZ1) consists of a tandem array of pentanucleotides. Nucleic Acids Research. ,vol. 14, pp. 7569- 7580 ,(1986) , 10.1093/NAR/14.19.7569
I. Oberle, D. Drayna, G. Camerino, R. White, J. L. Mandel, The telomeric region of the human X chromosome long arm: presence of a highly polymorphic DNA marker and analysis of recombination frequency. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 2824- 2828 ,(1985) , 10.1073/PNAS.82.9.2824
D Ginsburg, J H Antin, B R Smith, S H Orkin, J M Rappeport, Origin of cell populations after bone marrow transplantation. Analysis using DNA sequence polymorphisms. Journal of Clinical Investigation. ,vol. 75, pp. 596- 603 ,(1985) , 10.1172/JCI111736