Immunology at the University of Rochester

摘要: Immunology at the University of Rochester Medical Center is concentrated in Department Microbiology & Immunology, but it has long been an interdepartmental program with faculty both basic science and clinical departments centers throughout medical center. This dates back many decades several pivotal points which strong scientists were recruited that strengthened already existing research training efforts. One these was recruitment early 1970s Drs John Kappler Philippa Marrack, whose acumen evident. In addition, new units immunology infectious diseases created Medicine researchers hired. During this time, Dr David Smith his colleagues Pediatrics developed vaccine against Hemophilus influenzae type B, remarkably successful virtually eliminated meningitis. 1980, a joint effort between Cancer Center, Scott appointed Dean’s Professor ushered long-standing collaboration two administrative groups. additional four expertise T B cell immunology. recognition growing strength immunology, department name changed to Track within formally approved. The 1990s brought changes as Ignacio Sanz, molecular immunologist interested human immunoglobulin gene rearrangements head Clinical Immunology/Rheumatology Unit Medicine. He established group continues thrive led establishment funding Autoimmunity Excellence, interdisciplinary investigators by Sanz. era, another major advance made Robert Rose, then Ph.D. student mentors they papillomavirus (HPV)16 virus-like particle cervical cancer. 1999, change for occurred W. Vaccine Biology Tim Mosmann center continue tradition development Center. able quickly hire diverse young have added greatly intellectual environment community. also Human brings together assists developing techniques support development. Researchers study role immune system different diseases. Several Excellence are studying disease humans variety animal models [1, 2]. focus programs, represented issue studies on tumor metastases [3] heat shock proteins eliciting anti-tumor immunity [4], other exploring aspects important goal finding better therapies. Influenza focal point researchers, who active collaborations. These interactions resulted attainment New York Rochester, bringing all influenza pathogenesis, epidemiology, development. Other laboratories focusing protection organisms potential agents bioterrorism [5]. examining response bone addressing such arthritis osteoporosis [6]. Virtually kinds cells being studied including lymphocytes [1], [2, 4, 7–12], antigen presenting [12], platelets [13]. Many receptors how affect cellular functions explored. Examples include integrin molecules expressed wide range leucocytes [8] CD28 cells, its mechanisms stimulation [9]. Trafficking particular interest number terms [7, 8] function tissue sites inflammation [2] or growth [3]. Training students integral part community Rochester. Virology (IMV) one 10 graduate programs biological sciences As three tracks program, opportunity interact groups pathogens must respond. collaborative among laboratory An NIH grant first obtained 1986 successfully renewed over 20 years. grants relevant various pathogenesis bacteria viruses HIV well Scientist Training Program pursuing combined MD/Ph.D. degree contribute rich postdoctoral fellows. addition lecture style courses advanced seminar course, “Topics Immunology” member each year covering topics using multiple formats. Recent included “mucosal Immunology”, “evolution system”, “bioterrorism—the intersection microbiology”. weekly journal club “Research Progress” series regular basis. ample obtain experience their during series. A outside speakers further enhances exposure leaders With more than 80 students, IMV largest Currently, 35 working toward home Postbaccalaureate Research Education (PREP), designed encourage prepare underrepresented minority pursue doctorate. Additional information our available departmental website (http://www.urmc.rochester.edu/smd/mbi/index.htm). The history level vaccines advances. Essential success approaches collaborations contributions today we conduct cutting-edge train next generation immunologists.