Vitamin E supplementation increases circulating vitamin E metabolites tenfold in end-stage renal disease patients.

摘要: Vitamin E supplementation could elevate circulating vitamin metabolites while modulating oxidative and inflammatory status in end-stage renal failure patients undergoing hemodialysis. Plasma concentrations of carboxyethyl-hydroxychromanols (α-and γ-CEHC), ascorbic acid, α-and γ-tocopherols, E2-isoprostanes, biomarkers [tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), ferritin, C-reactive protein (CRP)] were measured blood samples obtained from (n=11) before after dialysis on two occasions prior to, at 1 2 mon daily (400 IU RRR-α-tocopherol). Supplementation nearly doubled plasma α-tocopherol (from 18±0.5 to 31±1.7 μM, P<0.0001), whereas γ-tocopherol decreased 2.8±0.3 1.7±0.2 P=0.001). Serum α-CEHC increased 10-fold 68±3 771±175 nM (P<0.0001), γ-CEHC 837±164 1136±230 (P=0.008). also postdialysis hematocrits 38±1% 41±1% (P<0.001). Dietary antioxidant intakes (vitamins C) low most subjects; acid levels (88±27 μM) significantly with (33±11 P=0.01). Il-6, CRP, TNF-α, free F2-isoprostane elevated throughout the study. There is a complex relationship between chronic inflammation stress that not mitigated by short-term supplementation. Importantly, serum metabolite within 30 d did increase further, suggesting routes other than urine for removal metabolites.