Cardiolipin and Mitochondrial Function in Health and Disease
作者： Giuseppe Paradies , Valeria Paradies , Francesca M. Ruggiero , Giuseppe Petrosillo
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摘要: Abstract Cardiolipin (CL) is a unique phospholipid that almost exclusively localized at the level of inner mitochondrial membrane (IMM), where it biosynthesized. This associated with membranes which are designed to generate an electrochemical gradient used produce ATP. Such include bacterial plasma and IMM. ubiquitous intimate association between CL energy-transducing suggests important role for in bioenergetic processes. has been shown interact number IMM proteins, including respiratory chain complexes substrate carriers. Moreover, involved different stages apoptosis process as well stability dynamics. Alterations structure, content, acyl composition have dysfunction multiple tissues several physiopathological conditions aging. In this review, we provide ...
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