Action of thiazide on renal interstitial calcium.

摘要: Our investigation of the calciuretic action salt loading1 reveals that Dahl salt-sensitive (DS) rats have higher basal renal cortical interstitial calcium (ISFCa2+) compared to salt-resistant (DR) and a high diet decreases ISFCa2+ in DS but not DR rats. The decrease was associated with an increase urinary excretion blood pressure rise following diet. When coupled vasodilatory increased extracellular calcium,2,3 these findings suggest may modulate secondary disruption calcium-dependent effect normally occurring region kidney. This study continues our dietary salt. Thiazides been shown be quite effective lowering pressure, particularly within African-American population.4 Although effectiveness diuretics is often ascribed volume reduction, it known subacute long-term thiazides subsequent fluid loss but, rather, vasodilation.5 mechanism this unknown. In light potential for alterations modulation vascular resistance,2,3 extremely important pathogenesis hypertension development. Of interest finding thiazides, addition increasing sodium loss, significantly reduce excretion.6,7 Therefore, designed determine whether thiazide treatment altered hypertension. To accomplish this, we measured 1 week hydrochlorothiazide (HCTZ) while on control or We report short-term HCTZ had no diet; however, reduced normal These antihypertensive due increases ISFCa2+.