Hypertension, sodium retention, calcium excretion and osteopenia in Dahl rats.

摘要: BACKGROUND: Salt-sensitive hypertension in the Dahl rat is associated with abnormalities both calcium (Ca2+) and sodium (Na) homeostasis. OBJECTIVE: To test hypothesis that salt-induced abnormal Ca(2+) handling salt-sensitive (DSS) rats negative balance bone disease. METHODS: excretion acute chronic Na(+) loading electrolyte water were determined by studies salt-resistant (DSR) fed 8 or 0.1% NaCl for 4 weeks. A dry ashing procedure was used to determine Na(+), Ca(2+), content their association blood pressure rats. RESULTS: When 8% NaCl, DSS initially maintained a positive showed decreased natriuresis compared DSR During course of loading, increased calciuresis. After weeks salt cumulative Na greater less than In addition, developed osteopenia. Bone mineral correlated inversely Acute saline volume expansion demonstrated ability excrete load fully, but led an exaggerated renal loss CONCLUSION: DSS, not DSR, develop ostopenia during loading. We speculate retention high diet may be part compensatory mechanism maintain balance.