Plasma 25-hydroxyvitamin D concentrations are inversely associated with blood pressure of Dahl salt-sensitive rats

摘要: Dietary salt is a contributing factor to the development of hypertension in individuals who are salt-sensitive. The vitamin D endocrine system has been reported modulate vascular structure and function. Since elderly hypertensive females with low plasma renin activity, typical salt-sensitivity, had significantly lower 25-hydroxyvitamin concentrations compared normotensive young females, we have used Dahl salt-sensitive salt-resistant rats fed high (80 g/kg diet) (3 diets as models examine relationship between salt-sensitivity D, precursor hormonal form 1,25-dihydroxyvitamin D. Plasma were unaffected by diet, but reduced within three weeks than 25%. There was negative association number days that diet (r = -0.98, P < 0.02) positive blood pressure 0.97, 0.05). An inverse found -0.99, 0.01). Spontaneously did not concentrations, suggesting reduction concentration might be specific salt-induced hypertension.