Vehicle effects on percutaneous absorption: in vivo and in vitro comparisons with human skin

摘要: The percutaneous absorption of benzoic acid, caffeine and testosterone through human skin was measured by using in vivo vitro techniques. compounds were applied to the solution three vehicles: petrolatum, ethylene glycol gel water gel. Because acid ionized at neutral pH gels, these data difficult interpret are not reported. stratum corneum/vehicle partition coefficients (Km) percent saturation vehicles with substrate determined aid interpretation results. In studies, permeability constants for each vehicle correlated either Km value or vehicle. Caffeine penetrated most readily from a petrolatum vehicle, greatest Permeation also expressed terms percentage dose absorbed. Reasonable agreement obtained between values. Although no significant differences occurred values compared, there trend toward lower penetration system.