Sex and tissue-specific differences in low-dose radiation-induced oncogenic signaling.

摘要: Purpose: The possible adverse health effects of low-dose radiation (LDR) exposure constitute a growing concern. Clinically and environmentally relevant exposures occur predominantly under chronic conditions, notwithstanding that most studies LDR have been performed using single acute exposure. Sex- tissue-specificity the LDR-induced changes not considered before. We investigated LDR-related expression patterns in muscle, liver spleen male female mice subjected to Genes involved oncogenic signaling were specific interest, as is well-known carcinogen.Materials methods: analyzed pattern genes coding for growth factors growth-factor receptors, cytoplasmic serine/threonine protein kinases, G-proteins nuclear DNA-binding proteins, other important components signaling.Results: found sex- tissue-specific Ras superfamily members (Nras, Rab2...