Dose-dependent differential expression of protein kinase C isozymes in mouse lymphocytes after gamma irradiation in vivo and ex vivo.

作者: Prajakta A. Varadkar , Malini Krishna , Naresh C. Verma

DOI: 10.1667/0033-7587(2003)159[0453:DDDEOP]2.0.CO;2

关键词: Protein kinase CIsozymeDifferential expressionEx vivoDose dependenceBiologyIn vivoMolecular biologyGamma irradiationPRKCD

摘要: … response of Prkcz was found to be similar to that of Prkcd. Prkc is a crucial enzyme that is being used to manipulate the response of tumors to radiotherapy. Conventional radiotherapy is …

参考文章(28)
Marian Mosior, Alexandra C. Newton, Mechanism of Interaction of Protein Kinase C with Phorbol Esters REVERSIBILITY AND NATURE OF MEMBRANE ASSOCIATION Journal of Biological Chemistry. ,vol. 270, pp. 25526- 25533 ,(1995) , 10.1074/JBC.270.43.25526
Su-Jae Lee, Chul-Koo Cho, Seong-Yul Yoo, Tae-Hwan Kim, Yun-Sil Lee, Influence of ionizing radiation on induction of apoptotic cell death and cellular redistribution of protein kinase C isozymes in mouse epidermal cells differing in carcinogenesis stages Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. ,vol. 426, pp. 41- 49 ,(1999) , 10.1016/S0027-5107(99)00078-0
Emiko Tsuchida, Muneyasu Urano, The effect of UCN-01 (7-hydroxystaurosporine), a potent inhibitor of protein kinase C, on fractionated radiotherapy or daily chemotherapy of a murine fibrosarcoma International Journal of Radiation Oncology Biology Physics. ,vol. 39, pp. 1153- 1161 ,(1997) , 10.1016/S0360-3016(97)00549-X
Tom K. Hei, Robert S. Krauss, Su X. Liu, Eric J. Hall, I.Bernard Weinstein, Effects of increased expression of protein kinase C on radiation-induced cell transformation. Carcinogenesis. ,vol. 15, pp. 365- 370 ,(1994) , 10.1093/CARCIN/15.2.365
Dennis E. Hallahan, Subbulakshmi Virudachalam, Jeffrey L. Schwartz, Nichole Panje, Reba Mustafi, Ralph R. Weichselbaum, Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation. Radiation Research. ,vol. 129, pp. 345- 350 ,(1992) , 10.2307/3578035
Norisato Mitsutake, Hiroyuki Namba, Stanislav S Shklyaev, Tomoo Tsukazaki, Akira Ohtsuru, Motoi Ohba, Toshio Kuroki, Hiroyoshi Ayabe, Shunichi Yamashita, PKC delta mediates ionizing radiation-induced activation of c-Jun NH(2)-terminal kinase through MKK7 in human thyroid cells. Oncogene. ,vol. 20, pp. 989- 996 ,(2001) , 10.1038/SJ.ONC.1204179
Adriana Haimovitz-Friedman, Radiation-Induced Signal Transduction and Stress Response Radiation Research. ,vol. 150, ,(1998) , 10.2307/3579812