Effect of moderate-intensity exercise training on GDNF signaling pathway in testicles of rats after experimental diabetes type 1 induction.
作者： Zahra Samadian , Asghar Tofighi , Mazdak Razi , Firouz Ghaderi Pakdel , Javad Tolouei Azar
DOI: 10.1016/J.DIABRES.2020.108332
关键词:
摘要: Abstract Aims The spermatogenesis failure is reported as the main complication for diabetes and moderate-intensity exercise (EX) shown to ameliorate diabetes-induced impairments both at sperm levels. Thus, current study was done investigate possible effect of EX in sole simultaneous form with insulin on network between Sertoli spermatogonial stem cells (SSCs) by focusing niche factor Glial cell-derived neurotrophic (GDNF). Methods For this purpose, 30 mature male Wistar rats were divided into control experimental type 1 (T1D)-induced groups. Then T1D-induced animals subdivided sedentary (ST1D), EX + T1D, (INS) + T1D EX + INS + T1D general histological changes testicles, mRNA protein contents GDNF its special receptors gfrα1 c-RET evaluated compared Results INS significantly (p Conclusion In conclusion, promotes up-regulating signaling system. Moreover, remarkably amplifies insulin-induced ameliorative spermatogenesis.
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